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Immunological correlates of protection mediated by a whole organism <i>Cryptococcus neoformans</i> vaccine deficient in chitosan

2024-06-14

Abstract excerpt

The global burden of infections due to the pathogenic fungus Cryptococcus is substantial in persons with low CD4 + T cell counts. Previously, we deleted three chitin deacetylase genes from C. neoformans to create a chitosan-deficient, avirulent strain, designated cda1Δ2Δ3Δ which, when used as a vaccine, protected mice from challenge with virulent C. neoformans strain KN99. Here, we explored the immunological...

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Literature Corpus work
2bf1efdd-f71b-5057-bbc0-0cf73f21a8d5
DOI
10.1101/2024.06.12.598760
Open publication

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Immunological correlates of protection mediated by a whole organism <i>Cryptococcus neoformans</i> vaccine deficient in chitosanDOI 10.1101/2024.06.12.598760
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