Article
Protective antifungal memory CD8(+) T cells are maintained in the absence of CD4(+) T cell help and cognate antigen in mice.
The Journal of clinical investigation - 1 Mar 2012
Nanjappa Som G, Heninger Erika, Wüthrich Marcel, Sullivan Thomas, Klein Bruce
Abstract excerpt
Individuals who are immunocompromised, including AIDS patients with few CD4(+) T cells, are at increased risk for opportunistic fungal infections. The incidence of such infections is increasing worldwide, meaning that the need for antifungal vaccines is increasing. Although CD4(+) T cells play a dominant role in resistance to many pathogenic fungal infections, we have previously shown that vaccination can induce...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.