Aspartate Transaminases Are Dispensable for Pancreatic Development and Pancreatic Cancer Progression

Abstract excerpt

Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer-related deaths in the United States. This is due in part to the limited availability of effective treatment options for patients, highlighting a significant need for new targets and approaches. Deregulated metabolism is a hallmark feature of PDA that has gained attention as a promising inroad for therapy. The aspartate transaminases ( g l...

Topics

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• Cancer, Hypoxia, and Metabolism
• Cancer-related Molecular Pathways
• Carcinoma, Pancreatic Ductal
• Metabolism, Diabetes, and Cancer
• Pancreatic and Hepatic Oncology Research
• Pancreatic Neoplasms
• Phenotype
• Telomeres, Telomerase, and Senescence

Identifiers and source

Literature Corpus work

b9f0e765-e5ba-57bd-b1cc-04c63e7cf222

DOI

10.64898/2025.12.17.694916