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Tim-3 promotes tube formation and decreases tight junction formation in vascular endothelial cells

1 Oct 2020

Abstract excerpt

As a negative immune checkpoint molecule, T-cell immunoglobulin domain and mucin domain containing molecule-3 (Tim-3) has been found to serve a crucial role in immune escape and tumour progression. Previous studies have reported that Tim-3 is important to endothelial cells and it has also been demonstrated to be involved in numerous types of human diseases, including melanoma, lymphoma, rickettsial infection and...

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PMID: 33015716
DOI: 10.1042/bsr20202130

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