Article

GDF15 is a dynamic biomarker of the Integrated Stress Response in the central nervous system

2023-08-27

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Aim</h4> Characterize Growth Differentiation Factor 15 (GDF15) as a secreted biomarker of the Integrated Stress Response (ISR) within the Central Nervous System (CNS). <h4>Methods</h4> We determined GDF15 levels utilizing in vitro and in vivo neuronal systems wherein the ISR was activated. Primarily, we used the murine model of Vanishing White Matter disease (VWMD), a neurological diseas...

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Literature Corpus work: 2bcc9042-b9dc-5e42-b9c2-19e5a43b7c2d
DOI: 10.1101/2023.08.25.554842

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