Vismodegib as First-Line Treatment of Mutated Sonic Hedgehog Pathway in Adult Medulloblastoma

Abstract excerpt

Medulloblastoma (MB) is an aggressive, primitive neuroectodermal tumor mainly affecting pediatric patients and with frequent involvement of the posterior fossa and extraneural metastasis. MB has a low incidence in adults (< 1% of adult brain tumors) and treatment protocols for adult patients have been adapted from pediatric oncology.1,2 PTCH13 tumor suppressor gene functions as an inhibitor of smoothened (SMO)...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Genomics and Chromatin Dynamics
• Share to Glioma Diagnosis and Treatment
• Share to Hedgehog Signaling Pathway Studies