Article
The transcriptional landscape of Shh medulloblastoma.
Nature communications - 19 Mar 2021
Skowron Patryk, Farooq Hamza, Cavalli Florence M G, Morrissy A Sorana, Ly Michelle, Hendrikse Liam D, Wang Evan Y, Djambazian Haig, Zhu Helen, Mungall Karen L, Trinh Quang M, Zheng Tina, Dai Shizhong, Stucklin Ana S Guerreiro, Vladoiu Maria C, Fong Vernon, Holgado Borja L, Nor Carolina, Wu Xiaochong, Abd-Rabbo Diala, Bérubé Pierre, Wang Yu Chang, Luu Betty, Suarez Raul A, Rastan Avesta, Gillmor Aaron H, Lee John J Y, Zhang Xiao Yun, Daniels Craig, Dirks Peter, Malkin David, Bouffet Eric, Tabori Uri, Loukides James, Doz François P, Bourdeaut Franck, Delattre Olivier O, Masliah-Planchon Julien, Ayrault Olivier, Kim Seung-Ki, Meyronet David, Grajkowska Wieslawa A, Carlotti Carlos G, de Torres Carmen, Mora Jaume, Eberhart Charles G, Van Meir Erwin G, Kumabe Toshihiro, French Pim J, Kros Johan M, Jabado Nada, Lach Boleslaw, Pollack Ian F, Hamilton Ronald L, Rao Amulya A Nageswara, Giannini Caterina, Olson James M, Bognár László, Klekner Almos, Zitterbart Karel, Phillips Joanna J, Thompson Reid C, Cooper Michael K, Rubin Joshua B, Liau Linda M, Garami Miklós, Hauser Peter, Li Kay Ka Wai, Ng Ho-Keung, Poon Wai Sang, Yancey Gillespie G, Chan Jennifer A, Jung Shin, McLendon Roger E, Thompson Eric M, Zagzag David, Vibhakar Rajeev, Ra Young Shin, Garre Maria Luisa, Schüller Ulrich, Shofuda Tomoko, Faria Claudia C, López-Aguilar Enrique, Zadeh Gelareh, Hui Chi-Chung, Ramaswamy Vijay, Bailey Swneke D, Jones Steven J, Mungall Andrew J, Moore Richard A, Calarco John A, Stein Lincoln D, Bader Gary D, Reimand Jüri, Ragoussis Jiannis, Weiss William A, Marra Marco A, Suzuki Hiromichi, Taylor Michael D
Abstract excerpt
Sonic hedgehog medulloblastoma encompasses a clinically and molecularly diverse group of cancers of the developing central nervous system. Here, we use unbiased sequencing of the transcriptome across a large cohort of 250 tumors to reveal differences among molecular subtypes of the disease, and demonstrate the previously unappreciated importance of non-coding RNA transcripts. We identify alterations within the...
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