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Article

De novo human genome assemblies reveal spectrum of alternative haplotypes in diverse populations.

Nature communications - 2 Aug 2018

Wong Karen H Y, Levy-Sakin Michal, Kwok Pui-Yan

Abstract excerpt

The human reference genome is used extensively in modern biological research. However, a single consensus representation is inadequate to provide a universal reference structure because it is a haplotype among many in the human population. Using 10× Genomics (10×G) "Linked-Read" technology, we perform whole genome sequencing (WGS) and de novo assembly on 17 individuals across five populations. We identify 1842...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 30072691
DOI: 10.1038/s41467-018-05513-w
PMCID: PMC6072799

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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