Article

Disturbance in Hebbian-like spinogenesis blunted learning-induced modulation in the number and spatial distribution of dendritic spines

2022-06-24

Abstract excerpt

<title>Abstract</title> <p>Neurotrypsin (NT) is a neuronal trypsin-like serine protease whose mutations cause severe mental retardation in humans. NT is activated by Hebbian-like conjunction of pre- and postsynaptic activities, which promotes the formation of dendritic filopodia via proteolytic cleavage of the proteoglycan agrin. Here, we investigated the functional importance of this mechanism for synaptic plast...

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Literature Corpus work: 2b93afea-bd2f-5c62-be14-a8e39fbfe583
DOI: 10.21203/rs.3.rs-1740340/v1

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