Article
Psychiatric risk factor ANK3/ankyrin-G nanodomains regulate the structure and function of glutamatergic synapses.
Neuron - 22 Oct 2014
Smith Katharine R, Kopeikina Katherine J, Fawcett-Patel Jessica M, Leaderbrand Katherine, Gao Ruoqi, Schürmann Britta, Myczek Kristoffer, Radulovic Jelena, Swanson Geoffrey T, Penzes Peter
Abstract excerpt
Recent evidence implicates glutamatergic synapses as key pathogenic sites in psychiatric disorders. Common and rare variants in the ANK3 gene, encoding ankyrin-G, have been associated with bipolar disorder, schizophrenia, and autism. Here we demonstrate that ankyrin-G is integral to AMPAR-mediated synaptic transmission and maintenance of spine morphology. Using superresolution microscopy we find that ankyrin-G...
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