β-III Spectrin Is Critical for Development of Purkinje Cell Dendritic Tree and Spine Morphogenesis

Abstract excerpt

Mutations in the gene encoding β-III spectrin give rise to spinocerebellar ataxia type 5, a neurodegenerative disease characterized by progressive thinning of the molecular layer, loss of Purkinje cells and increasing motor deficits. A mouse lacking full-length β-III spectrin (β-III⁻/⁻) displays a similar phenotype. In vitro and in vivo analyses of Purkinje cells lacking β-III spectrin, reveal a critical role for...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Cellular Mechanics and Interactions
• Share to Erythrocyte Function and Pathophysiology
• Share to Neuroscience and Neuropharmacology Research