Article

Ciliopathy interacts with neonatal anesthesia to cause non-apoptotic caspase-mediated motor deficits

2024-11-27

Abstract excerpt

Increasing evidence suggests that anesthesia may induce developmental neurotoxicity, yet the influence of genetic predispositions associated with congenital anomalies on this toxicity remains largely unknown. Children with congenital heart disease often exhibit mutations in cilia-related genes and ciliary dysfunction, requiring sedation for their catheter or surgical interventions during the neonatal period. Here...

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Literature Corpus work: 4a561f13-8469-5e38-b465-c9d7c5121c66
DOI: 10.1101/2024.11.27.624302

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