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Article

Oncogenic Human Papillomaviruses Drive One-Third of Sinonasal Squamous Cell Carcinoma and Are Not Mutually Exclusive for Gene Mutations.

Head & neck - 1 Jun 2025

Henrion Maxime, Costes-Martineau Valérie, Bravo Ignacio González, Boulle Nathalie, Solassol Jérôme, Vendrell Julie, Garrel Renaud, Trinquet Aude, Lacheretz-Szablewski Vanessa

Abstract excerpt

BACKGROUND: The detection rate of oncogenic human papillomaviruses (HPVs) in sinonasal squamous cell carcinomas (SNSCCs) varies among studies. The mutational landscape of SNSCCs remains poorly investigated. METHODS: We investigated the prevalence and prognostic significance of HPV infections based on p16 protein expression, HPV-DNA detection, and E6/E7 mRNA expression using immunohistochemistry, polymerase chain...

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Share to Class I Phosphatidylinositol 3-Kinases
Share to Cyclin-Dependent Kinase Inhibitor p16

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Human Papillomavirus Viruses

Share to In Situ Hybridization

Share to Papillomaviridae

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Share to Paranasal Sinus Neoplasms

Share to Receptor, Fibroblast Growth Factor, Type 3

Source

Open in PubMed Open full text

Identifiers

PMID: 39865501
DOI: 10.1002/hed.28084
PMCID: PMC12068539

Genes

CDKN2A
EGFR
FGFR3
PIK3CA
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

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