Article
Celastrol induces DNA damage and cell death in BCR-ABL T315I-mutant CML by targeting YY1 and HMCES.
Phytomedicine : international journal of phytotherapy and phytopharmacology - 1 Nov 2024
Yang Fan, Zhou Hongchao, Luo Piao, Jia Lin, Hou Mengyun, Huang Jingnan, Gao Lin, Zhang Qian, Guan Yudong, Bao Honglei, Zhang Baotong, Liu Liping, Zou Chang, Yang Qinhe, Wang Jigang, Dai Lingyun
Abstract excerpt
BACKGROUND: Chronic myeloid leukemia (CML) is driven primarily by the constitutively active BCR-ABL fusion oncoprotein. Although the development of tyrosine kinase inhibitors has markedly improved the prognosis of CML patients, it remains a significant challenge to overcome drug-resistant mutations, such as the T315I mutation of BCR-ABL, and achieve treatment-free remission in the clinic. PURPOSE: The...
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