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A proteolysis-targeting chimera molecule selectively degrades ENL and inhibits malignant gene expression and tumor growth

8 Apr 2022

Abstract excerpt

BACKGROUND: Chromosome translocations involving mixed lineage leukemia 1 (MLL1) cause acute leukemia in most infants and 5-10% children/adults with dismal clinical outcomes. Most frequent MLL1-fusion partners AF4/AFF4, AF9/ENL and ELL, together with CDK9/cyclin-T1, constitute super elongation complexes (SEC), which promote aberrant gene transcription, oncogenesis and maintenance of MLL1-rearranged (MLL1-r)...

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PMID: 35395864
DOI: 10.1186/s13045-022-01258-8

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