Article

Transcriptomic signatures of brain regional vulnerability to Parkinson’s disease

2019-06-10

Abstract excerpt

The molecular mechanisms underlying the caudal-to-rostral progression of Lewy body pathology in Parkinson’s disease (PD) remain poorly understood. Here, we aimed to unravel transcriptomic signatures across brain regions involved in Braak Lewy body stages in non-neurological controls and PD donors. Using human postmortem brain datasets of non-neurological adults from the Allen Human Brain Atlas, we identified expre...

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Literature Corpus work: 95d577a5-3abb-5330-9608-759ec0559ac1
DOI: 10.1101/664771

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