Article
Identification and Characterization of Novel Antibody Epitopes on the N2 Neuraminidase.
mSphere - 10 Feb 2021
Kirkpatrick Roubidoux Ericka, McMahon Meagan, Carreño Juan Manuel, Capuano Christina, Jiang Kaijun, Simon Viviana, van Bakel Harm, Wilson Patrick, Krammer Florian
Abstract excerpt
The influenza virus neuraminidase (NA) is becoming a focus for novel vaccine designs. However, the epitopes of human anti-NA antibodies have been poorly defined. Using a panel of 10 anti-N2 monoclonal antibodies (MAbs) that bind the H3N2 virus A/Switzerland/9715293/2013, we generated five escape mutant viruses. These viruses contained mutations K199E/T, E258K, A272D, and S331N. We found that mutations at K199 and...
Topics
- A549 Cells
- Animals
- Antibodies, Monoclonal
- Antibodies, Viral
- Antigens, Viral
- Dogs
- Epitopes
- Hemagglutinin Glycoproteins, Influenza Virus
- Humans
- Influenza A Virus, H3N2 Subtype