Article

Entrenchment of germline amino-acid differences in antibody affinity maturation

2026-04-23

Abstract excerpt

Entrenchment — epistasis that locks in amino acid differences between homologous proteins, so each disfavors substitutions toward the other’s state — has been demonstrated along individual protein lineages over deep evolutionary time. Antibodies offer a unique system for studying entrenchment: multiple homologous germline V gene paralogs provide diverse starting points, and the rapid somatic evolution of affinity...

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Literature Corpus work: 2b19afa7-a67d-573c-bd00-60c875bebe62
DOI: 10.64898/2026.04.21.720000

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