Article

IDH-mutant gliomas arise from glial progenitor cells harboring the initial driver mutation

2024-10-21

Abstract excerpt

Discovering the cell-of-origin harboring the initial driver mutation provides a fundamental basis for understanding tumor evolution and development of new treatments. For isocitrate dehydrogenase (IDH)-mutant gliomas – the most common malignant primary brain tumors in adults under 50 – the cell-of-origin remains poorly understood. Here, using patient brain tissues and genome-edited mice, we identified glial progen...

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Literature Corpus work: 2b09beb9-8ecb-557b-a1b3-84863304cf96
DOI: 10.1101/2024.10.17.618976

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