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Article

Human glioblastoma arises from subventricular zone cells with low-level driver mutations.

Nature - 1 Aug 2018

Lee Joo Ho, Lee Jeong Eun, Kahng Jee Ye, Kim Se Hoon, Park Jun Sung, Yoon Seon Jin, Um Ji-Yong, Kim Woo Kyeong, Lee June-Koo, Park Junseong, Kim Eui Hyun, Lee Ji-Hyun, Lee Joon-Hyuk, Chung Won-Suk, Ju Young Seok, Park Sung-Hong, Chang Jong Hee, Kang Seok-Gu, Lee Jeong Ho

Abstract excerpt

Glioblastoma (GBM) is a devastating and incurable brain tumour, with a median overall survival of fifteen months1,2. Identifying the cell of origin that harbours mutations that drive GBM could provide a fundamental basis for understanding disease progression and developing new treatments. Given that the accumulation of somatic mutations has been implicated in gliomagenesis, studies have suggested that neural stem...

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PMID: 30069053
DOI: 10.1038/s41586-018-0389-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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