Article
An NF-κB Transcription-Factor-Dependent Lineage-Specific Transcriptional Program Promotes Regulatory T Cell Identity and Function.
Immunity - 19 Sept 2017
Oh Hyunju, Grinberg-Bleyer Yenkel, Liao Will, Maloney Dillon, Wang Pingzhang, Wu Zikai, Wang Jiguang, Bhatt Dev M, Heise Nicole, Schmid Roland M, Hayden Matthew S, Klein Ulf, Rabadan Raul, Ghosh Sankar
Abstract excerpt
Both conventional T (Tconv) cells and regulatory T (Treg) cells are activated through ligation of the T cell receptor (TCR) complex, leading to the induction of the transcription factor NF-κB. In Tconv cells, NF-κB regulates expression of genes essential for T cell activation, proliferation, and function. However the role of NF-κB in Treg function remains unclear. We conditionally deleted canonical NF-κB members...
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