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Article

The transcriptional control of the perforin locus

28 Apr 2010

Abstract excerpt

SUMMARY: Natural killer (NK) cells and cytotoxic T lymphocytes (CTLs) use cytotoxic granules containing perforin and granzymes to lyse infected or malignant host cells, thereby providing immunity to intracellular microbes and tumors. Perforin is essential for cytotoxic granule-mediated killing. Perforin expression is regulated transcriptionally and correlates tightly with the development of cells that can exhibit...

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PMID: 20536555
DOI: 10.1111/j.0105-2896.2010.00905.x

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