Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The transcription factors c-rel and RelA control epidermal development and homeostasis in embryonic and adult skin via distinct mechanisms.

Molecular and cellular biology - 1 Jul 2004

Gugasyan Raffi, Voss Anne, Varigos George, Thomas Tim, Grumont Raelene J, Kaur Pritinder, Grigoriadis George, Gerondakis Steve

Abstract excerpt

Determining the roles of Rel/NF-kappaB transcription factors in mouse skin development with loss-of-function mutants has been limited by redundancy among these proteins and by embryonic lethality associated with the absence of RelA. Using mice lacking RelA and c-rel, which survive throughout embryogenesis on a tumor necrosis factor alpha (TNF-alpha)-deficient background (rela(-/-) c-rel(-/-) tnfalpha(-/-)), we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Embryo, Mammalian
Share to Hair Follicle

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeostasis

Share to NF-kappa B

Share to Proto-Oncogene Proteins c-rel

Share to Transcription Factor RelA

Share to Tumor Necrosis Factor-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 15199130
DOI: 10.1128/MCB.24.13.5733-5745.2004
PMCID: PMC480872

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The transcription factors c-rel and RelA control epidermal development and homeostasis in embryonic and adult skin via distinct mechanisms.PMID 15199130Read ↗

Epidermal RelA specifically restricts contact allergen-induced inflammation and apoptosis in skin.Semantic proximity Read ↗

Requirement of NF-kappaB/Rel for the development of hair follicles and other epidermal appendices.Semantic proximity Read ↗

The c-Rel Subunit of NF-κB Regulates Epidermal Homeostasis and Promotes Skin Fibrosis in MiceSemantic proximity Read ↗

Cutting Edge: NF-κB p65 and c-Rel Control Epidermal Development and Immune Homeostasis in the SkinSemantic proximity Read ↗

Genetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: transgenics and knockouts.Semantic proximity Read ↗

Immortalized embryonic mouse fibroblasts lacking the RelA subunit of transcription factor NF-kappaB have a malignantly transformed phenotype.Semantic proximity Read ↗

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel familySemantic proximity Read ↗

IKK1-deficient mice exhibit abnormal development of skin and skeleton.Semantic proximity Read ↗

TNFalpha shedding and epidermal inflammation are controlled by Jun proteins.Semantic proximity Read ↗

Loss of epithelial RelA results in deregulated intestinal proliferative/apoptotic homeostasis and susceptibility to inflammation.Semantic proximity Read ↗

Activin controls skin morphogenesis and wound repair predominantly via stromal cells and in a concentration-dependent manner via keratinocytes.Semantic proximity Read ↗

AP-2α/AP-2β transcription factors are key regulators of epidermal homeostasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.