Article

Decreased substrate stiffness leads to mitochondrial dysfunctions and Endothelial to Mesenchymal transition through Focal Adhesion Kinase activity in corneal endothelial cells

2025-11-08

Abstract excerpt

<h4>Purpose</h4> Fuchs’ Endothelial Corneal Dystrophy (FECD), a degenerative corneal disorder, is marked by the thickening of Descemet’s membrane and a progressive loss of corneal endothelial cells, ultimately leading to vision loss. A feature associated with the disease is the reduced stiffness of Descemet’s membrane. However, the effects of this change in Descemet’s membrane, on corneal endothelial cell health...

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Literature Corpus work: 2ad024ea-d28c-58ab-9aae-53019d798a9b
DOI: 10.1101/2025.11.08.687366

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