Article
The Sins of Our Forefathers: Paternal Impacts on De Novo Mutation Rate and Development.
Annual review of genetics - 23 Nov 2020
Aitken R John, De Iuliis Geoffry N, Nixon Brett
Abstract excerpt
Spermatogonial stem cells (SSCs) are generally characterized by excellent DNA surveillance and repair, resulting in one of the lowest spontaneous mutation rates in the body. However, the barriers to mutagenesis can be overwhelmed under two sets of circumstances. First, replication errors may generate age-dependent mutations that provide the mutant cells with a selective advantage, leading to the clonal expansions...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.