Effective Utilization of a Customized Targeted Hybrid Capture RNA Sequencing in the Routine Molecular Categorization of Adolescent and Adult B-Lineage Acute Lymphoblastic Leukemia: A Real-World Experience.

doi:10.1007/s40291-025-00779-5

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Effective Utilization of a Customized Targeted Hybrid Capture RNA Sequencing in the Routine Molecular Categorization of Adolescent and Adult B-Lineage Acute Lymphoblastic Leukemia: A Real-World Experience.

Molecular diagnosis & therapy - 1 May 2025

Sreedharanunni Sreejesh, Thakur Venus, Balakrishnan Anand, Sachdeva Man Updesh Singh, Kaur Prabhjot, Raina Sudhanshi, Jamwal Manu, Singh Charanpreet, Sharma Praveen, Mallik Nabhajit, Naseem Shano, Rastogi Pulkit, Jain Arihant, Prakash Gaurav, Khadwal Alka, Malhotra Pankaj, Das Reena

Abstract excerpt

INTRODUCTION: Recent World Health Organization (WHO) and International Consensus Classifications have introduced numerous molecular entities in B-lineage acute lymphoblastic leukemia (B-ALL), necessitating comprehensive genomic characterization by detecting gene fusions, expression, mutations, and exon deletions. While whole-genome plus transcriptome sequencing is the ideal strategy, it remains cost-prohibitive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to In Situ Hybridization, Fluorescence

Share to Oncogene Proteins, Fusion

Share to Precursor B-Cell Lymphoblastic Leukemia-Lymphoma

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Identifiers

PMID: 40186692
DOI: 10.1007/s40291-025-00779-5

Genes

ABL1
BCR
IGH
IKZF1
AFF1
DUX4
ETV6
KMT2A
PBX1
RUNX1
TCF3

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