Article
Identification and characterization of novel classes of macrophage migration inhibitory factor (MIF) inhibitors with distinct mechanisms of action.
The Journal of biological chemistry - 20 Aug 2010
Ouertatani-Sakouhi Hajer, El-Turk Farah, Fauvet Bruno, Cho Min-Kyu, Pinar Karpinar Damla, Le Roy Didier, Dewor Manfred, Roger Thierry, Bernhagen Jürgen, Calandra Thierry, Zweckstetter Markus, Lashuel Hilal A
Abstract excerpt
Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, is considered an attractive therapeutic target in multiple inflammatory and autoimmune disorders. In addition to its known biologic activities, MIF can also function as a tautomerase. Several small molecules have been reported to be effective inhibitors of MIF tautomerase activity in vitro. Herein we employed a robust activity-based assay...
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