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Computational Structural Biology of S-nitrosylation of Cancer Targets

14 Aug 2018

Abstract excerpt

Nitric oxide (NO) plays an essential role in redox signaling in normal and pathological cellular conditions. In particular, it is well known to react in vivo with cysteines by the so-called S-nitrosylation reaction. S-nitrosylation is a selective and reversible post-translational modification that exerts a myriad of different effects, such as the modulation of protein conformation, activity, stability and,...

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Identifiers

PMID: 30155439
DOI: 10.3389/fonc.2018.00272

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