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Article

Characterization of molecular determinants of the conformational stability of macrophage migration inhibitory factor: leucine 46 hydrophobic pocket.

PloS one - 1 Jan 2012

El-Turk Farah, Fauvet Bruno, Ashrafi Amer, Ouertatani-Sakouhi Hajer, Cho Min-Kyu, Neri Marilisa, Cascella Michele, Rothlisberger Ursula, Pojer Florence, Zweckstetter Markus, Lashuel Hilal

Abstract excerpt

Macrophage Migration Inhibitory Factor (MIF) is a key mediator of inflammatory responses and innate immunity and has been implicated in the pathogenesis of several inflammatory and autoimmune diseases. The oligomerization of MIF, more specifically trimer formation, is essential for its keto-enol tautomerase activity and probably mediates several of its interactions and biological activities, including its binding...

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Share to Hydrophobic and Hydrophilic Interactions
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23028743
DOI: 10.1371/journal.pone.0045024
PMCID: PMC3448610

Genes

MIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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