Article
Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis.
Nature genetics - 1 Jul 2020
Vujkovic Marijana, Keaton Jacob M, Lynch Julie A, Miller Donald R, Zhou Jin, Tcheandjieu Catherine, Huffman Jennifer E, Assimes Themistocles L, Lorenz Kimberly, Zhu Xiang, Hilliard Austin T, Judy Renae L, Huang Jie, Lee Kyung M, Klarin Derek, Pyarajan Saiju, Danesh John, Melander Olle, Rasheed Asif, Mallick Nadeem H, Hameed Shahid, Qureshi Irshad H, Afzal Muhammad Naeem, Malik Uzma, Jalal Anjum, Abbas Shahid, Sheng Xin, Gao Long, Kaestner Klaus H, Susztak Katalin, Sun Yan V, DuVall Scott L, Cho Kelly, Lee Jennifer S, Gaziano J Michael, Phillips Lawrence S, Meigs James B, Reaven Peter D, Wilson Peter W, Edwards Todd L, Rader Daniel J, Damrauer Scott M, O'Donnell Christopher J, Tsao Philip S, Chang Kyong-Mi, Voight Benjamin F, Saleheen Danish
Abstract excerpt
We investigated type 2 diabetes (T2D) genetic susceptibility via multi-ancestry meta-analysis of 228,499 cases and 1,178,783 controls in the Million Veteran Program (MVP), DIAMANTE, Biobank Japan and other studies. We report 568 associations, including 286 autosomal, 7 X-chromosomal and 25 identified in ancestry-specific analyses that were previously unreported. Transcriptome-wide association analysis detected...
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