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Exploring the mechanism and pattern of bone formation during RANKL inhibition in a mouse model of fibrous dysplasia

2025-08-30

Abstract excerpt

Fibrous dysplasia (FD) of bone is a genetic fibro-osseous disorder with increased bone remodeling activity. Inhibition of RANKL modifies FD lesions by inducing the replacement of the fibrous tissue with bone. This effect was observed in FD murine models receiving anti-mouse RANKL antibodies or small molecule RANKL inhibitors and in FD patients treated with denosumab. However, in neither case the mechanism and patt...

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Identifiers and source

Literature Corpus work
2a9a1045-0d5d-536e-913b-e76c711c4883
DOI
10.1101/2025.08.26.672317
Open publication

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Exploring the mechanism and pattern of bone formation during RANKL inhibition in a mouse model of fibrous dysplasiaDOI 10.1101/2025.08.26.672317
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