Article

RANKL inhibition with denosumab improves fibrous dysplasia by decreasing lesional cell proliferation and increasing osteogenesis

2022-10-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Fibrous dysplasia (FD) is a rare, disabling disease with no established treatments. Growing evidence supports inhibiting the pro-osteoclastic factor receptor activator of nuclear Kappa-B ligand (RANKL) as a potential treatment strategy. We conducted a phase 2 trial evaluating the anti-RANKL drug denosumab in adults with FD, with an emphasis on investigating post-discontinuatio...

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Literature Corpus work: a85f4871-e1de-5886-90d7-b59e76b04cce
DOI: 10.1101/2022.10.24.22281375

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