Article

Transcriptomic signature and pro-osteoclastic secreted factors of abnormal bone marrow stromal cells in fibrous dysplasia

2024-02-28

Abstract excerpt

Fibrous dysplasia (FD) is a mosaic skeletal disorder caused by somatic activating variants in GNAS , encoding for Gα s , which leads to excessive cAMP signaling in bone marrow stromal cells (BMSCs). Despite advancements in our understanding of FD pathophysiology, the effect of Gα s activation in the BMSC transcriptome remains unclear, as well as how this translates into their local influence in the lesional mic...

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Literature Corpus work: 5351717c-41dd-5a86-b7cd-8ea198b6d7bf
DOI: 10.1101/2024.02.23.581225

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