Article
Denosumab treatment for fibrous dysplasia.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jul 2012
Boyce Alison M, Chong William H, Yao Jack, Gafni Rachel I, Kelly Marilyn H, Chamberlain Christine E, Bassim Carol, Cherman Natasha, Ellsworth Michelle, Kasa-Vubu Josephine Z, Farley Frances A, Molinolo Alfredo A, Bhattacharyya Nisan, Collins Michael T
Abstract excerpt
Fibrous dysplasia (FD) is a skeletal disease caused by somatic activating mutations of the cyclic adenosine monophosphate (cAMP)-regulating protein, α-subunit of the Gs stimulatory protein (G(s) α). These mutations lead to replacement of normal bone by proliferative osteogenic precursors, resulting in deformity, fracture, and pain. Medical treatment has been ineffective in altering the disease course. Receptor...
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