Article

Efficient <i>in vivo</i> pharmacological inhibition of ΔFOSB, an AP1 transcription factor, in brain

2025-10-23

Abstract excerpt

<h4>ABSTRACT</h4> ΔFOSB, an unusually stable member of the AP1 family of transcription factors, mediates long-term maladaptations that play a key role in the pathogenesis of drug addiction, cognitive decline, dyskinesias, and several other chronic neurological and psychiatric conditions. We have recently identified that 2-phenoxybenzenesulfonic acid-containing compounds disrupt the binding of ΔFOSB to DNA in vit...

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Literature Corpus work: 2a97f201-d440-5b07-aac4-bda435c9e32d
DOI: 10.1101/2025.10.21.683721

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