Article

Integrated Computational Screening and Dynamics Simulations Uncover Sulfonamide-Indole Hybrids as Potent CBP Bromodomain Inhibitors

2026-04-01

Abstract excerpt

<title>Abstract</title> <p>Epigenetic dysregulation, particularly via bromodomain-mediated recognition of histone acetylation, drives oncogenic gene expression in cancers, including prostate and acute myeloid leukemia, positioning the CREB-binding protein (CBP) bromodomain as a key therapeutic target for disrupting pro-proliferative programs without genetic alteration. While inhibitors like CCS1477 advance clinic...

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Literature Corpus work: e74d28d8-c52a-5755-bf73-293cbcd8bfc2
DOI: 10.21203/rs.3.rs-9152561/v1

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Integrated Computational Screening and Dynamics Simulations Uncover Sulfonamide-Indole Hybrids as Potent CBP Bromodomain InhibitorsDOI 10.21203/rs.3.rs-9152561/v1Read

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