Transcription Factors and Methods for the Pharmacological Correction of Their Activity

Abstract excerpt

Transcription factors (TFs) are proteins that control gene expression by binding to specific DNA sequences and are essential for cell development, differentiation, and homeostasis. Dysregulation of TFs is implicated in numerous diseases, including cancer, autoimmune disorders, and neurodegeneration. While TFs were traditionally considered "undruggable" due to their lack of well-defined binding pockets, recent...

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