Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbar muscular atrophy.

doi:10.1038/nm.4500

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Article

Selective modulation of the androgen receptor AF2 domain rescues degeneration in spinal bulbar muscular atrophy.

Nature medicine - 1 May 2018

Badders Nisha M, Korff Ane, Miranda Helen C, Vuppala Pradeep K, Smith Rebecca B, Winborn Brett J, Quemin Emmanuelle R, Sopher Bryce L, Dearman Jennifer, Messing James, Kim Nam Chul, Moore Jennifer, Freibaum Brian D, Kanagaraj Anderson P, Fan Baochang, Tillman Heather, Chen Ping-Chung, Wang Yingzhe, Freeman Burgess B, Li Yimei, Kim Hong Joo, La Spada Albert R, Taylor J Paul

Abstract excerpt

Spinal bulbar muscular atrophy (SBMA) is a motor neuron disease caused by toxic gain of function of the androgen receptor (AR). Previously, we found that co-regulator binding through the activation function-2 (AF2) domain of AR is essential for pathogenesis, suggesting that AF2 may be a potential drug target for selective modulation of toxic AR activity. We screened previously identified AF2 modulators for their...

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PMID: 29505030
DOI: 10.1038/nm.4500
PMCID: PMC5975249

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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