Article
MAIT cell inhibition promotes liver fibrosis regression via macrophage phenotype reprogramming.
Nature communications - 1 Apr 2023
Mabire Morgane, Hegde Pushpa, Hammoutene Adel, Wan Jinghong, Caër Charles, Sayegh Rola Al, Cadoux Mathilde, Allaire Manon, Weiss Emmanuel, Thibault-Sogorb Tristan, Lantz Olivier, Goodhardt Michèle, Paradis Valérie, de la Grange Pierre, Gilgenkrantz Hélène, Lotersztajn Sophie
Abstract excerpt
Recent data have shown that liver fibrosis can regress even at later stages of cirrhosis and shifting the immune response from pro-inflammatory towards a resolutive profile is considered as a promising option. The immune regulatory networks that govern the shift of the inflammatory phenotype and thus potential reversal of liver fibrosis are lesser known. Here we show that in precision-cut human liver slices...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.