Article

Oncogenic Transformation of Human Mammary Epithelial Cells by Autocrine Human Growth Hormone

2005-01-01

Abstract excerpt

Abstract The human growth hormone (hGH) gene is expressed in the normal human mammary epithelial cell and its expression increases concomitant with the acquisition of proliferative lesions. Herein we demonstrate that autocrine production of hGH in human mammary carcinoma cells dramatically enhances anchorage-independent growth in a Janus kinase 2–dependent manner. Forced expression of the hGH gene in immortalized...

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Literature Corpus work: 2a8f9391-929c-5032-b6f8-d97a7694e293
DOI: 10.1158/0008-5472.317.65.1

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