Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phenotypic conversion of human mammary carcinoma cells by autocrine human growth hormone.

Proceedings of the National Academy of Sciences of the United States of America - 19 Oct 2004

Mukhina Svetlana, Mertani Hichem C, Guo Ke, Lee Kok-Onn, Gluckman Peter D, Lobie Peter E

Abstract excerpt

We report here that autocrine production of human growth hormone (hGH) results in a phenotypic conversion of mammary carcinoma cells such that they exhibit the morphological and molecular characteristics of a mesenchymal cell, including expression of fibronectin and vimentin. Autocrine production of hGH resulted in reduced plakoglobin expression and relocalization of E-cadherin to the cytoplasm, leading to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autocrine Communication
Share to Cell Movement

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Neoplasm

Share to Human Growth Hormone

Share to Mesoderm

Share to Neoplasm Invasiveness

Share to Recombinant Proteins

Share to Transfection

Source

Open in PubMed Open full text

Identifiers

PMID: 15353581
DOI: 10.1073/pnas.0405881101
PMCID: PMC524067

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotypic conversion of human mammary carcinoma cells by autocrine human growth hormone.PMID 15353581Read ↗

DNMT3A and DNMT3B mediate autocrine hGH repression of plakoglobin gene transcription and consequent phenotypic conversion of mammary carcinoma cells.Semantic proximity Read ↗

Oncogenic Transformation of Human Mammary Epithelial Cells by Autocrine Human Growth HormoneSemantic proximity Read ↗

Review of: Oncogenic transformation of human mammary epithelial cells by autocrine human growth hormoneSemantic proximity Read ↗

Gene Expression Profiling to Identify Oncogenic Determinants of Autocrine Human Growth Hormone in Human Mammary CarcinomaSemantic proximity Read ↗

Multiple aspects of the phenotype of mammary epithelial cells transformed by expression of activated M-Ras depend on an autocrine mechanism mediated by hepatocyte growth factor/scatter factor.Semantic proximity Read ↗

The invasive phenotype in HMT-3522 cells requires increased EGF receptor signaling through both PI 3-kinase and ERK 1,2 pathways.Semantic proximity Read ↗

Heregulin regulates the actin cytoskeleton and promotes invasive properties in breast cancer cell lines.Semantic proximity Read ↗

Progastrin overexpression imparts tumorigenic/metastatic potential to embryonic epithelial cells: phenotypic differences between transformed and nontransformed stem cells.Semantic proximity Read ↗

TGF-beta-induced upregulation of MMP-2 and MMP-9 depends on p38 MAPK, but not ERK signaling in MCF10A human breast epithelial cells.Semantic proximity Read ↗

Plakoglobin Regulates the Expression of the Anti-apoptotic Protein BCL-2Semantic proximity Read ↗

Development of an Autocrine Neuregulin Signaling Loop with Malignant Transformation of Human Breast Epithelial CellsSemantic proximity Read ↗

Phenotypic characterization of collagen gel embedded primary human breast epithelial cells in athymic nude mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.