Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human pituitary tumor-transforming gene 1 overexpression reinforces oncogene-induced senescence through CXCR2/p21 signaling in breast cancer cells.

Breast cancer research : BCR - 12 Jul 2012

Ruan Jhen-Wei, Liao Yi-Chu, Lua Ingrid, Li Ming-Hsun, Hsu Chih-Yi, Chen Ji-Hshiung

Abstract excerpt

INTRODUCTION: hPTTG1 (human pituitary tumor-transforming gene 1) is an oncogene overexpressed in breast cancer and several other types of cancer. Increased hPTTG1 expression has been shown to be associated with poor patient outcomes in breast cancer. Although hPTTG1 overexpression plays important roles in promoting the proliferation, invasion, and metastasis of cancer cells, it also has been suggested to induce...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cellular Senescence
Share to Epithelial Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ligands

Share to Neoplasm Invasiveness

Share to Neoplasm Metastasis

Share to Proto-Oncogene Proteins p21(ras)

Share to Receptors, Interleukin-8B

Share to Securin

Source

Open in PubMed Open full text

Identifiers

PMID: 22789011
DOI: 10.1186/bcr3226
PMCID: PMC3680924

Genes

CXCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human pituitary tumor-transforming gene 1 overexpression reinforces oncogene-induced senescence through CXCR2/p21 signaling in breast cancer cells.PMID 22789011Read ↗

PTTG1 Oncogene Promotes Tumor Malignancy via Epithelial to Mesenchymal Transition and Expansion of Cancer Stem Cell PopulationSemantic proximity Read ↗

YB-1 IS REQUIRED FOR THE GENESIS AND METASTATIC CAPACITY OF HUMAN BREAST CANCERSemantic proximity Read ↗

PTTG1 attenuates drug-induced cellular senescence.Semantic proximity Read ↗

Hypoxia-inducible factor-1 facilitates cervical cancer progression in human papillomavirus type 16 transgenic mice.Semantic proximity Read ↗

Pttg1 Promotes Growth of Breast Cancer through P27 Nuclear ExclusionSemantic proximity Read ↗

Overexpression of the pituitary tumor transforming gene induces p53-dependent senescence through activating DNA damage response pathway in normal human fibroblasts.Semantic proximity Read ↗

Autocrine signaling in hormonally active cancer induces antigen expression for immunotherapySemantic proximity Read ↗

Ectopic expression of PTTG1/securin promotes tumorigenesis in human embryonic kidney cells.Semantic proximity Read ↗

E2F1 Induces Pituitary Tumor Transforming Gene (PTTG1) Expression in Human Pituitary TumorsSemantic proximity Read ↗

RNAi-mediated knockdown of pituitary tumor- transforming gene-1 (PTTG1) suppresses the proliferation and invasive potential of PC3 human prostate cancer cellsSemantic proximity Read ↗

Twist1-induced suppression of oncogene-induced senescence in non-small cell lung cancer requires the transactivation domain of Twist1Semantic proximity Read ↗

Pituitary tumour-transforming gene (PTTG) and pituitary senescence.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.