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Frequency of CDK2 , CCNE1 Copy Number Variation in Acral Melanoma and Implications for CDK Inhibitor in Targeted Therapy

2020-02-12

Abstract excerpt

<h4>Background: </h4> Acral melanoma have a high frequency of cell cycle-related gene copy number variation. However, the status and clinical significance of CNVs of CDK 2 and CCNE1 have not been fully elucidated. <h4>Methods:</h4> A total of 490 acral melanoma samples were examined for CNVs of CDK 2 and CCNE1 using QuantiGenePlex DNA Assay. Correlations of CDK2 and CCNE1 CNVs to clinicopathologic features and pro...

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Literature Corpus work
2a8f1650-52ce-56e0-a516-cc1e5df3822b
DOI
10.21203/rs.2.23330/v1
Open publication

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