Article
Frequent Genetic Aberrations in the CDK4 Pathway in Acral Melanoma Indicate the Potential for CDK4/6 Inhibitors in Targeted Therapy.
Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Nov 2017
Kong Yan, Sheng Xinan, Wu Xiaowen, Yan Junya, Ma Meng, Yu Jiayi, Si Lu, Chi Zhihong, Cui Chuanliang, Dai Jie, Li Yiqian, Yu Huan, Xu Tianxiao, Tang Huan, Tang Bixia, Mao Lili, Lian Bin, Wang Xuan, Yan Xieqiao, Li Siming, Guo Jun
Abstract excerpt
Purpose: Effective therapies for the majority of metastatic acral melanoma patients have not been established. Thus, we investigated genetic aberrations of CDK4 pathway in acral melanoma and evaluated the efficacy of CDK4/6 inhibitors in targeted therapy of acral melanoma.Experimental Design: A total of 514 primary acral melanoma samples were examined for the copy number variations (CNV) of CDK4 pathway-related...
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