Conjunctival melanomas harbor BRAF and NRAS mutations and copy number changes similar to cutaneous and mucosal melanomas.

doi:10.1158/1078-0432.CCR-13-0163

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Article

Conjunctival melanomas harbor BRAF and NRAS mutations and copy number changes similar to cutaneous and mucosal melanomas.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jun 2013

Griewank Klaus G, Westekemper Henrike, Murali Rajmohan, Mach Monika, Schilling Bastian, Wiesner Thomas, Schimming Tobias, Livingstone Elisabeth, Sucker Antje, Grabellus Florian, Metz Claudia, Süsskind Daniela, Hillen Uwe, Speicher Michael R, Woodman Scott E, Steuhl Klaus-Peter, Schadendorf Dirk

Abstract excerpt

PURPOSE: Conjunctival melanoma is a rare but potentially deadly tumor of the eye. Despite effective local therapies, recurrence and metastasis remain frequent. Once the tumor has metastasized, treatment options are limited and the prognosis is poor. To date, little is known of the genetic alterations in conjunctival melanomas. EXPERIMENTAL DESIGN: We conducted genetic analysis of 78 conjunctival melanomas, to our...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23633454
DOI: 10.1158/1078-0432.CCR-13-0163

Genes

BRAF
NRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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