Article

Cisplatin is more mutagenic than carboplatin or oxaliplatin at equitoxic concentrations

2020-08-12

Abstract excerpt

<h4>ABSTRACT</h4> Platinum-based drugs are a mainstay of cancer chemotherapy. However, their mutagenic effect can increase tumour heterogeneity, contribute to the evolution of treatment resistance, and also induce secondary malignancies. We coupled whole genome sequencing with phenotypic investigations on two cell line models to compare the magnitude and understand the mechanism of mutagenicity of cisplatin, carb...

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Literature Corpus work: 2a868df4-7e8e-5268-9dc3-b1eb674470fe
DOI: 10.1101/2020.08.11.245969

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