Article
Mutations recovered in the Chinese hamster aprt gene after exposure to carboplatin: a comparison with cisplatin.
Carcinogenesis - 1 Jan 1992
de Boer J G, Glickman B W
Abstract excerpt
Platinum-based compounds such as cisplatin and carboplatin are currently used for the treatment of a variety of solid tumors. Their primary mode of action involves the production of cross-links in DNA. These compounds induce mutations in bacterial as well as in mammalian cells. Previously we dete...
Topics
- Adenine Phosphoribosyltransferase
- Animals
- Base Sequence
- CHO Cells
- Carboplatin
- Cisplatin
- Cricetinae
- DNA
- Molecular Sequence Data
- Mutation