Article

Stabilization of the Metastable Prefusion Conformation of SARS-CoV-2 Spike Glycoprotein through N-linked Glycosylation on S2 Subunit

2023-12-20

Abstract excerpt

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the novel coronavirus responsible for the coronavirus disease 2019 (COVID-19) pandemic, represents a serious threat to public health. The spike (S) glycoprotein of SARS-CoV-2 mediates viral entry into host cells and is heavily glycosylated. In this study, we systemically analyzed the roles of 22 putative N-linked glycans in SARS-CoV-2 S protein expressi...

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Literature Corpus work: 2a6e65c5-a09d-5006-be53-ddd2648d1a59
DOI: 10.20944/preprints202312.1504.v1

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