Article
Multilevel Genomics-Based Taxonomy of Renal Cell Carcinoma.
Cell reports - 15 Mar 2016
Chen Fengju, Zhang Yiqun, Şenbabaoğlu Yasin, Ciriello Giovanni, Yang Lixing, Reznik Ed, Shuch Brian, Micevic Goran, De Velasco Guillermo, Shinbrot Eve, Noble Michael S, Lu Yiling, Covington Kyle R, Xi Liu, Drummond Jennifer A, Muzny Donna, Kang Hyojin, Lee Junehawk, Tamboli Pheroze, Reuter Victor, Shelley Carl Simon, Kaipparettu Benny A, Bottaro Donald P, Godwin Andrew K, Gibbs Richard A, Getz Gad, Kucherlapati Raju, Park Peter J, Sander Chris, Henske Elizabeth P, Zhou Jane H, Kwiatkowski David J, Ho Thai H, Choueiri Toni K, Hsieh James J, Akbani Rehan, Mills Gordon B, Hakimi A Ari, Wheeler David A, Creighton Chad J
Abstract excerpt
On the basis of multidimensional and comprehensive molecular characterization (including DNA methalylation and copy number, RNA, and protein expression), we classified 894 renal cell carcinomas (RCCs) of various histologic types into nine major genomic subtypes. Site of origin within the nephron was one major determinant in the classification, reflecting differences among clear cell, chromophobe, and papillary...
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