Sarcomatoid Renal Cell Carcinoma Has a Distinct Molecular Pathogenesis, Driver Mutation Profile, and Transcriptional Landscape.

doi:10.1158/1078-0432.CCR-17-1057

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Article

Sarcomatoid Renal Cell Carcinoma Has a Distinct Molecular Pathogenesis, Driver Mutation Profile, and Transcriptional Landscape.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2017

Wang Zixing, Kim Tae Beom, Peng Bo, Karam Jose, Creighton Chad, Joon Aron, Kawakami Fumi, Trevisan Patricia, Jonasch Eric, Chow Chi-Wan, Canales Jaime Rodriguez, Tamboli Pheroze, Tannir Nizar, Wood Christopher, Monzon Federico, Baggerly Keith, Varella-Garcia Marileila, Czerniak Bogdan, Wistuba Ignacio, Mills Gordon, Shaw Kenna, Chen Ken, Sircar Kanishka

Abstract excerpt

Purpose: Sarcomatoid renal cell carcinoma (SRCC) ranks among the most aggressive clinicopathologic phenotypes of RCC. However, the paucity of high-quality, genome-wide molecular examinations of SRCC has hindered our understanding of this entity.Experimental Design: We interrogated the mutational, copy number, and transcriptional characteristics of SRCC and compared these data with those of nonsarcomatoid RCC...

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Identifiers

PMID: 28710314
DOI: 10.1158/1078-0432.CCR-17-1057
PMCID: PMC5683086

Genes

PTEN
RELN
VHL
PBRM1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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